The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein Cholesterol in Response to Hyzetimibe: A Factorial-Designed Clinical Trial
J Liao, L Yang, L Zhou, H Zhao, X Qi, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Background: Hyzetimibe is a novel inhibitor of cholesterol that specifically targets the
NPC1L1 gene. Significant inter-individual variability suggests the existence of an …
NPC1L1 gene. Significant inter-individual variability suggests the existence of an …
Exploring pleiotropic effects of lipid modifiers and targets on measures of the coagulation system with genetics
CM Schooling, SLA Yeung… - Thrombosis and …, 2022 - thieme-connect.com
Background Statins have long been suspected to have pleiotropic effects via thrombotic
factors. Randomized controlled trials are too limited to be definitive. We examined the …
factors. Randomized controlled trials are too limited to be definitive. We examined the …
基因检测在降脂药物个体化治疗中的应用
朱扬媚， 曹建刚， 周玉生 - 中国药房, 2023 - journal.china-pharmacy.com
血脂异常在临床上主要表现为高脂血症, 是导致动脉粥样硬化, 冠心病和脑卒中等心脑血管疾病
发生的重要危险因素. 临床上主要采用降脂药物进行治疗, 但存在个体差异, 基因影响等问题 …
发生的重要危险因素. 临床上主要采用降脂药物进行治疗, 但存在个体差异, 基因影响等问题 …
[PDF][PDF] Aperito Journal Cellular and Molecular Biology
CJ Wootena, M Assisoua, DT Agina, D Lopez - 2016 - researchgate.net
Abstract Niemann-Pick C1-Like 1 (NPC1L1) is expressed in human liver, but its mechanism
of action and how it is regulated in this tissue is not well-understood. Herein, we decided to …
of action and how it is regulated in this tissue is not well-understood. Herein, we decided to …