The role of oxidative stress in cardiovascular aging and cardiovascular diseases

C Izzo, P Vitillo, P Di Pietro, V Visco, A Strianese… - Life, 2021 - mdpi.com
Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

Cardiac aging: from molecular mechanisms to significance in human health and disease

DF Dai, T Chen, SC Johnson, H Szeto… - Antioxidants & redox …, 2012 - liebertpub.com
Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease

JL Fleg, J Strait - Heart failure reviews, 2012 - Springer
Important changes occur in the cardiovascular system with advancing age, even in
apparently healthy individuals. Thickening and stiffening of the large arteries develop due to …

Resistance exercise: good for more than just Grandma and Grandpa's muscles

SM Phillips - Applied Physiology, Nutrition, and Metabolism, 2007 - cdnsciencepub.com
Progressive resistance training promotes strength gains in both the young and the aged.
Importantly, gains in strength in aged persons are, with the appropriate duration, intensity …

Healthy aging and cardiovascular function: invasive hemodynamics during rest and exercise in 104 healthy volunteers

A Pandey, WE Kraus, PH Brubaker, DW Kitzman - Heart Failure, 2020 - jacc.org
Objectives The aim of this study was to evaluate the association between age and invasive
cardiovascular hemodynamics during upright exercise among healthy adults. Background …

The role of cardiac resident macrophage in cardiac aging

J Li, Y Xin, Z Wang, J Li, W Li, H Li - Aging Cell, 2023 - Wiley Online Library
Advancements in longevity research have provided insights into the impact of cardiac aging
on the structural and functional aspects of the heart. Notable changes include the gradual …

Associations of cardiac mechanics with exercise capacity: the multi-ethnic study of atherosclerosis

RB Patel, BH Freed, L Beussink-Nelson… - Journal of the American …, 2021 - jacc.org
Background Lower exercise capacity, as measured by 6-minute walk distance (6MWD), is
associated with incident heart failure (HF). Among those without HF, the associations of …

Quality control systems in cardiac aging

EK Quarles, DF Dai, A Tocchi, N Basisty, L Gitari… - Ageing research …, 2015 - Elsevier
Cardiac aging is an intrinsic process that results in impaired cardiac function, along with
cellular and molecular changes. These degenerative changes are intimately associated with …

Assessment of adult age differences in task engagement: The utility of systolic blood pressure

TM Hess, GE Ennis - Motivation and Emotion, 2014 - Springer
The constructs of effort and engagement are central to many theoretical frameworks
associated with the study of aging. Age differences in the effort associated with effortful …

Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?

S Boudina - Current Pharmaceutical Design, 2013 - ingentaconnect.com
Intrinsic cardiac aging is an independent risk factor for cardiovascular disease and is
associated with structural and functional changes that impede cardiac responses to stress …