Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study

LA Cysique, D Jakabek, SG Bracken, Y Allen-Davidian… - Medrxiv, 2022 - medrxiv.org
Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly
understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients …

Machine learning approaches to understand cognitive phenotypes in people with HIV

SS Mukerji, KJ Petersen, KM Pohl… - The Journal of …, 2023 - academic.oup.com
Cognitive disorders are prevalent in people with HIV (PWH) despite antiretroviral therapy.
Given the heterogeneity of cognitive disorders in PWH in the current era and evidence that …

Individual differences in CD4/CD8 T-cell ratio trajectories and associated risk profiles modeled from acute HIV infection

R Paul, K Cho, J Bolzenius, C Sacdalan… - Psychosomatic …, 2022 - journals.lww.com
Objective We examined individual differences in CD4/CD8 T-cell ratio trajectories and
associated risk profiles from acute HIV infection (AHI) through 144 weeks of antiretroviral …

Development of a refined harmonization approach for longitudinal cognitive data in people with HIV

L Lang, LH Rubin, RM Dastgheyb, DE Vance… - Journal of Clinical …, 2025 - Elsevier
Objectives The aim of this study was to develop a refined method for harmonizing
longitudinal cognitive data across several large-scale studies in people with HIV (PWH), in …

Latent Profile Analysis of Cognitive Performance and Depressive Symptoms Among People with HIV

M Kohli, L Ham, R Saloner, D Dung… - AIDS Patient Care …, 2024 - liebertpub.com
Depression and cognitive impairment are prevalent conditions among people with HIV
(PWH), likely attributable to shared causes and common risk factors. Identifying subtypes of …

[HTML][HTML] The interaction of HIV with mental health in the modern antiretroviral therapy era

AW Carrico, LH Rubin, RH Paul - Psychosomatic medicine, 2022 - journals.lww.com
People with HIV (PWH) receiving effective antiretroviral therapy (ART) continue to display
residual immune dysregulation that amplifies the risk for neuropsychiatric comorbidities. At …

The Patient Generated Index (PGI) as an early-warning system for predicting brain health challenges: a prospective cohort study for people living with Human …

MM Humayun, MJ Brouillette, LK Fellows… - Quality of Life …, 2023 - Springer
Purpose In research people are often asked to fill out questionnaires about their health and
functioning and some of the questions refer to serious health concerns. Typically, these …

Brain volumetrics differ by Fiebig stage in acute HIV infection

J Bolzenius, C Sacdalan, LC Ndhlovu, N Sailasuta… - AIDS, 2023 - journals.lww.com
Objective: People with chronic HIV exhibit lower regional brain volumes compared to people
without HIV (PWOH). Whether imaging alterations observed in chronic infection occur in …

The Patient Generated Index as an early-warning system for predicting brain health challenges: A prospective cohort study for people living with HIV

MM Humayun - 2023 - escholarship.mcgill.ca
This thesis is a part of the longitudinal cohort study entitled,“Understanding and optimizing
brain health in HIV now” conceived by Dr. Lesley Fellows, Dr. Marie-Josée Brouillette and …

Mitigating cognitive impairment in people with HIV by targeting potential impacts of toxoplasmic infection

J Bolzenius, BK Agan - AIDS, 2024 - journals.lww.com
People with HIV (PWH) are at increased risk for opportunistic infections, resulting in further
morbidity and mortality. Opportunistic infections cause additional burden on an immune …