The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

The dynamic behavior of epithelial cell sheets plays a central role during numerous
developmental processes. Genetic and imaging studies of epithelial morphogenesis in a …

During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

How tissue shape emerges from the collective mechanical properties and behavior of
individual cells is not understood. We combine experiment and theory to study this problem …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and …

Endothelial cells show surprising cell rearrangement behaviour during angiogenic
sprouting; however, the underlying mechanisms and functional importance remain unclear …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …