Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Metastasis, therapy failure and tumour recurrence are major clinical challenges in cancer.
The interplay between tumour‐initiating cells (TICs) and epithelial–mesenchymal transition …

Abstract Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response
to hypoxia and its transcriptional activity is crucial for cancer cell mobility. Here we present …

Previous reports suggested that cinnamaldehyde (CA), the bioactive ingredient in
Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities …

Upregulation of glycolysis, induction of epithelial–mesenchymal transition (EMT) and
macroautophagy (hereafter autophagy), are phenotypic changes that occur in tumor cells, in …

Autophagy is a critical cellular process that generally protects cells and organisms from
harsh environment, including limitations in adenosine triphosphate (ATP) availability or a …

Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and
glioblastoma multiforme (GBM) progression. In response to hypoxia, GBM cells are able to …

Autophagy is a critical factor in eukaryotic evolution. Cells provide nutrition and energy
during autophagy by destroying non-essential components, thereby allowing intracellular …

Although autophagy is a well-known and extensively described cell pathway, numerous
studies have been recently interested in studying the importance of its regulation at different …

Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate
due to its infiltrative growth, treatment resistance, intra-and intertumoral genetic …