Pharmacological targeting of endoplasmic reticulum stress in disease
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
Structure and molecular mechanism of ER stress signaling by the unfolded protein response signal activator IRE1
CJ Adams, MC Kopp, N Larburu, PR Nowak… - Frontiers in molecular …, 2019 - frontiersin.org
The endoplasmic reticulum (ER) is an important site for protein folding and maturation in
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
A Almanza, A Carlesso, C Chintha… - The FEBS …, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …
compartment of the secretory pathway. As such, the ER contributes to the production and …
[HTML][HTML] Endoplasmic reticulum stress signaling in cancer cells
SA Oakes - The American journal of pathology, 2020 - Elsevier
To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
Osteoblast/osteoclast and immune cocktail therapy of an exosome/drug delivery multifunctional hydrogel accelerates fracture repair
B Mi, L Chen, Y Xiong, Y Yang, AC Panayi, H Xue… - ACS …, 2022 - ACS Publications
The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed
fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can …
fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can …
Pharmacological targeting of the unfolded protein response for disease intervention
Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …
many human diseases including obesity, liver disorders, cancer, diabetes and …
The role of endoplasmic reticulum stress in human pathology
SA Oakes, FR Papa - Annual Review of Pathology: Mechanisms …, 2015 - annualreviews.org
Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …
Targeting the unfolded protein response in disease
Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …
is a feature of specialized secretory cells and is also observed in many diseases, including …
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress
Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane
multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins …
multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins …