Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …

Permanent availability of red blood cells (RBCs) for transfusion depends on refrigerated
storage, during which morphologically altered RBCs accumulate. Among these, a …

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …

Red blood cells (RBCs) deformability refers to the cells' ability to adapt their shape to the
dynamically changing flow conditions so as to minimize their resistance to flow. The high red …

Stored red blood cells (RBCs) incur biochemical and morphological changes, collectively
termed the storage lesion. Functionally, the storage lesion manifests as slower oxygen …

BACKGROUND Biological and technical variability has been increasingly appreciated as a
key factor impacting red blood cell (RBC) storability and, potentially, transfusion outcomes …

Background Increases in the red blood cell (RBC) degree of fatty acid desaturation are
reported in response to exercise, aging, or diseases associated with systemic oxidant stress …

Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …