Biology and evolution of bacterial toxin–antitoxin systems

D Jurėnas, N Fraikin, F Goormaghtigh… - Nature Reviews …, 2022 - nature.com
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …

An insider's perspective: Bacteroides as a window into the microbiome

AG Wexler, AL Goodman - Nature microbiology, 2017 - nature.com
Over the last decade, our appreciation for the contribution of resident gut microorganisms—
the gut microbiota—to human health has surged. However, progress is limited by the sheer …

The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

Bacterial antagonism in host-associated microbial communities

L García-Bayona, LE Comstock - Science, 2018 - science.org
BACKGROUND Microbial communities are ubiquitous on Earth. The microbiota of different
habitats are diverse and have distinct functional traits, but there are common ecological …

[HTML][HTML] Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them

MT Sorbara, EG Pamer - Mucosal immunology, 2019 - Elsevier
The communities of bacteria that reside in the intestinal tract are in constant competition
within this dynamic and densely colonized environment. At homeostasis, the equilibrium that …

Type VI secretion system effector proteins: effective weapons for bacterial competitiveness

RE Hernandez, R Gallegos‐Monterrosa… - Cellular …, 2020 - Wiley Online Library
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …

Activity, delivery, and diversity of Type VI secretion effectors

D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …

The diverse functional roles of elongation factor Tu (EF-Tu) in microbial pathogenesis

KL Harvey, VM Jarocki, IG Charles… - Frontiers in …, 2019 - frontiersin.org
Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of
aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical …

The Pseudomonas putida T6SS is a plant warden against phytopathogens

P Bernal, LP Allsopp, A Filloux, MA Llamas - The ISME journal, 2017 - academic.oup.com
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver
toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial …

Multifaceted interfaces of bacterial competition

RM Stubbendieck, PD Straight - Journal of bacteriology, 2016 - Am Soc Microbiol
Microbial communities span many orders of magnitude, ranging in scale from hundreds of
cells on a single particle of soil to billions of cells within the lumen of the gastrointestinal …