Despite the considerable advances in medical and pharmaceutical research during the past
years, diseases caused by viruses have remained a major burden to public health. Virtual in …

Adenosine is an ubiquitous local modulator that regulates various physiological and
pathological functions by stimulating four membrane receptors, namely A1, A2A, A2B, and …

FLAP fingerprints are applied in the ligand-, structure-and pharmacophore-based mode in a
case study on antagonists of all four adenosine receptor (AR) subtypes. Structurally diverse …

The discovery and development of adenosine receptor antagonists have represented for
years an attractive field of research from the perspective of identifying new drugs for the …

The purine nucleoside adenosine is identified as a ubiquitous molecule regulator of different
tissues and cell functions. 1 Adenosine is generated in the extracellular space by the …

An efficient four-component reaction of 6-amino-1, 3-dimethyluracil, N, N-dimethylformamide
dimethylacetal, 1-phenyl-3-(4-substituted-phenyl)-4-formyl-1H-pyrazoles and aromatic …

Fragment-based strategy in drug design involves the initial discovery of low-molecular mass
molecules. Owing to their small-size, fragments are molecular tools to probe specific sub …

Background: Microbial diseases, specifically originating from viruses are the major cause of
human mortality all over the world. The current COVID-19 pandemic is a case in point …

The key concept in chemogenomics is the similarity principle that states that similar ligands
should bind similar targets. Chemogenomic analysis requires large amounts of data and …

An efficient synthetic procedure was adopted to synthesize a series of new molecules
containing the pyrazolo [3, 4-d] pyrimidine (PP) scaffold, which have been evaluated as …