Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological …

Background Blood–brain barrier (BBB) disruption is a major adverse event after ischemic
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …

Neuroprotectant strategies that have worked in rodent models of stroke have failed to
provide protection in clinical trials. Here we show that the opposite circadian cycles in …

Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

Brain edema is one of the most devastating consequences of ischemic stroke. Malignant
cerebral edema is the main reason accounting for the high mortality rate of large …

Globally, stroke is a leading cause of death and long-term disability. Over the past decades,
several efforts have attempted to discover new drugs or repurpose existing therapeutics to …