DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
[HTML][HTML] RHOJ controls EMT-associated resistance to chemotherapy
M Debaugnies, S Rodríguez-Acebes, J Blondeau… - Nature, 2023 - nature.com
The resistance of cancer cells to therapy is responsible for the death of most patients with
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …
A genetic map of the response to DNA damage in human cells
M Olivieri, T Cho, A Álvarez-Quilón, K Li… - Cell, 2020 - cell.com
The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …
The Fanconi anaemia pathway: new players and new functions
The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …
understanding of this complex pathway is still evolving, as new components continue to be …
Mechanisms of oncogene-induced replication stress: jigsaw falling into place
P Kotsantis, E Petermann, SJ Boulton - Cancer discovery, 2018 - AACR
Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …
of changes in the genome that contribute to genomic instability, which accelerates mutation …
RPA and RAD51: fork reversal, fork protection, and genome stability
Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …
Smarcal1-mediated fork reversal triggers Mre11-dependent degradation of nascent DNA in the absence of Brca2 and stable Rad51 nucleofilaments
AM Kolinjivadi, V Sannino, A De Antoni, K Zadorozhny… - Molecular cell, 2017 - cell.com
Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks,
leading to cell lethality. To understand the molecular mechanisms underlying this process …
leading to cell lethality. To understand the molecular mechanisms underlying this process …
RAD51 Gene Family Structure and Function
B Bonilla, SR Hengel, MKK Grundy… - Annual review of …, 2020 - annualreviews.org
Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
Restoration of replication fork stability in BRCA1-and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …
repair factors protect stalled replication forks upon replication stress. Previous studies have …