Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with
multiple therapeutic avenues to lower amyloid-β burden in Alzheimer's disease (AD). In …

Curcumin has a long history of use as a traditional remedy and food in Asia. Many studies
have reported that curcumin has various beneficial properties, such as antioxidant …

Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …

Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …

Mitochondria contribute to shape intraneuronal Ca2+ signals. Excessive Ca2+ taken up by
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …

Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important
process in brain health and diseases such as Alzheimer's disease (AD) and cerebral …

Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …

Mixed pathology, with both Alzheimer's disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which has been …

Through a comprehensive analysis of organellar markers in mouse models of Alzheimer's
disease, we document a massive accumulation of lysosome-like organelles at amyloid …