[HTML][HTML] A perspective on anti-EGFR therapies targeting triple-negative breast cancer

K Nakai, MC Hung, H Yamaguchi - American journal of cancer …, 2016 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC), which lacks estrogen receptor (ER), progesterone
receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for about 15 …

Therapeutic targets in triple negative breast cancer

SA O'Toole, JM Beith, EKA Millar, R West… - Journal of clinical …, 2013 - jcp.bmj.com
Outcomes have improved significantly for many women diagnosed with breast cancer. For
the heterogeneous group of tumours lacking expression of the oestrogen, progesterone and …

[HTML][HTML] High EGFR gene copy number predicts poor outcome in triple-negative breast cancer

HS Park, MH Jang, EJ Kim, HJ Kim, HJ Lee, YJ Kim… - Modern pathology, 2014 - Elsevier
Epidermal growth factor receptor (EGFR) is frequently overexpressed in triple-negative
breast cancer and is emerging as a therapeutic target. EGFR gene copy number alteration …

Targeting epidermal growth factor‐overexpressing triple‐negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor

Y Liu, Y Zhou, KH Huang, X Fang, Y Li… - Cell …, 2020 - Wiley Online Library
Objectives Traditional cancer therapy and regular immunotherapy are ineffective for treating
triple‐negative breast cancer (TNBC) patients. Recently, chimeric antigen receptor …

[HTML][HTML] EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC

Y Liu, Y Zhou, KH Huang, Y Li, X Fang, L An… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is an aggressive cancer subtype for which effective
therapies are lacking. Epidermal growth factor receptor (EGFR) is overexpressed in various …

Therapeutic landscape in mutational triple negative breast cancer

Y Shi, J Jin, W Ji, X Guan - Molecular cancer, 2018 - Springer
Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior
and poor prognosis. Genomic sequencing has detected a distinctive mutational portrait of …

Biopsies: next-generation biospecimens for tailoring therapy

M Basik, A Aguilar-Mahecha, C Rousseau… - Nature reviews Clinical …, 2013 - nature.com
The majority of samples in existing tumour biobanks are surgical specimens of primary
tumours. Insights into tumour biology, such as intratumoural heterogeneity, tumour–host …

Potentiating therapeutic effects of epidermal growth factor receptor inhibition in triple-negative breast cancer

KS You, YW Yi, J Cho, JS Park, YS Seong - Pharmaceuticals, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is a subset of breast cancer with aggressive
characteristics and few therapeutic options. The lack of an appropriate therapeutic target is a …

EGFR and KRAS Mutations Predict the Incidence and Outcome of Brain Metastases in Non-Small Cell Lung Cancer

P Tomasini, C Serdjebi, N Khobta, P Metellus… - International journal of …, 2016 - mdpi.com
Background: Lung cancer is the leading cause of brain metastases (BM). The identification
of driver oncogenes and matched targeted therapies has improved outcome in non-small …

Association between Parkinson disease and risk of cancer in Taiwan

PY Lin, SN Chang, TH Hsiao, BT Huang, CH Lin… - JAMA …, 2015 - jamanetwork.com
Importance Parkinson disease (PD) has been reported to be associated with a general
reduced risk of cancer. These studies were mainly carried out in Western populations and …