Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning

K Röltgen, SD Boyd - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
As the COVID-19 pandemic has evolved during the past years, interactions between human
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …

Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection

S Miyamoto, T Nishiyama, A Ueno… - Proceedings of the …, 2023 - National Acad Sciences
Infectious virus shedding from individuals infected with severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2) is used to estimate human-to-human transmission risk. Control …

[HTML][HTML] Role of the humoral immune response during COVID-19: guilty or not guilty?

M Yaugel-Novoa, T Bourlet, S Paul - Mucosal Immunology, 2022 - Elsevier
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …

[HTML][HTML] BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age

TA Bates, P Lu, YJ Kang, D Schoen, M Thornton… - Cell Reports, 2022 - cell.com
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews
concerns about decreased vaccine neutralization weakening efficacy. However, while …

BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?

A Darwich, C Pozzi, G Fornasa, M Lizier… - EMBO molecular …, 2022 - embopress.org
Vaccination against an airborne pathogen is very effective if it induces also the development
of mucosal antibodies that can protect against infection. The mRNA‐based vaccine …

Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS‐CoV‐2 infection

S Sheikh‐Mohamed, EC Sanders… - Immunological …, 2022 - Wiley Online Library
In early 2020, a global emergency was upon us in the form of the coronavirus disease 2019
(COVID‐19) pandemic. While horrific in its health, social and economic devastation, one …

Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: A rapid systematic review

ENS Guerra, VT Castro, J Amorim dos Santos… - Frontiers in …, 2022 - frontiersin.org
Since the introduction of efficient vaccines anti-SARS-CoV-2, antibody quantification
becomes increasingly useful for immunological monitoring and COVID-19 control. In several …

Natural SARS-CoV-2 infection affects neutralizing activity in saliva of vaccinees

M Garziano, O Utyro, M Poliseno… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 transmission mainly occurs through exposure of the upper airway
mucosa to infected secretions such as saliva, which are excreted by an infected person …

Methodological approaches to optimize multiplex oral fluid SARS-CoV-2 IgG assay performance and correlation with serologic and neutralizing antibody responses

N Pisanic, AAR Antar, KL Kruczynski, MG Rivera… - Journal of …, 2023 - Elsevier
Background Oral fluid (hereafter, saliva) is a non-invasive and attractive alternative to blood
for SARS-CoV-2 IgG testing; however, the heterogeneity of saliva as a matrix poses …