The Role of TAM Receptors in Bone
J Engelmann, D Ragipoglu, I Ben-Batalla… - International Journal of …, 2023 - mdpi.com
The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic
regulators of adult tissue homeostasis maintaining organ integrity and self-renewal …
regulators of adult tissue homeostasis maintaining organ integrity and self-renewal …
High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel …
J Quester, M Nethander, E Coward, E Reimann… - Calcified Tissue …, 2024 - Springer
The effects of androgens on women's bone health are not fully understood. Mendelian
randomization (MR) studies using sex-combined data suggest that sex hormone-binding …
randomization (MR) studies using sex-combined data suggest that sex hormone-binding …
[HTML][HTML] A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer
D Wu, J Zhou, L Song, Q Zheng, T Wang… - Translational Lung …, 2024 - tlcr.amegroups.org
Background: Observational studies have revealed a potential association between
gastroesophageal reflux disease (GERD) and lung cancer (LC), but the genetic role in their …
gastroesophageal reflux disease (GERD) and lung cancer (LC), but the genetic role in their …
[HTML][HTML] GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density
Over 1,100 independent signals have been identified with genome-wide association studies
(GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility …
(GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility …
TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling
J Engelmann, J Zarrer, MJ Schmerder, C Mess… - bioRxiv, 2024 - biorxiv.org
The TAM family of receptor tyrosine kinases were recently identified to regulate bone
homeostasis by controlling osteoblasts and bone formation. Despite extensive knowledge of …
homeostasis by controlling osteoblasts and bone formation. Despite extensive knowledge of …