Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At
high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain …

Background Anxiety and depression are two important contributors to the global burden of
disease. In many developing countries, including Nepal, their prevalences are yet to be …

Background: Emerging evidence indicates that NLRP3 inflammasome-induced inflammation
plays a crucial role in the pathogenesis of depression. Thus, inhibition of NLRP3 …

Suicide and major depressive disorder (MDD) are complex conditions that almost certainly
arise from the influences of many interrelated factors. There are significant regional …

Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by
suicide may be preventable, it is well documented that despite major governmental and …

Depressive disorders are frequently managed with long-term use of antidepressant
medication. Fluoxetine (FLX) is the first selective serotonin reuptake inhibitor to be widely …

Multiple studies suggest that the risks of depression and suicide increase with increasing
altitude of residence, but no studies have assessed whether changing altitude changes …

Our previous work has shown that d-ribose (RIB)-induced depressive-like behaviors in mice.
However, the relationship between variations in RIB levels and depression as well as …

Depression in children and adolescents has become a serious public health problem
worldwide. The objectives of this study were twofold: first, to investigate the status of …