[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
Global genomic diversity for All of Us
L Koch - Nature Reviews Genetics, 2024 - nature.com
Global genomic diversity for All of Us | Nature Reviews Genetics Skip to main content Thank
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[HTML][HTML] MUSSEL: enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …
variety of complex traits and diseases, but there exists a substantial performance gap across …
[HTML][HTML] Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease
OG Bhalala, R Watson, N Yassi - International Journal of Molecular …, 2024 - mdpi.com
Late-onset Alzheimer's disease is the leading cause of dementia worldwide, accounting for
a growing burden of morbidity and mortality. Diagnosing Alzheimer's disease before …
a growing burden of morbidity and mortality. Diagnosing Alzheimer's disease before …
[PDF][PDF] Power of inclusion: Enhancing polygenic prediction with admixed individuals
Y Tanigawa, M Kellis - The American Journal of Human Genetics, 2023 - cell.com
Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admixed populations, with their unique and diverse genetic backgrounds, are often
underrepresented in genetic studies. This oversight not only limits our understanding but …
underrepresented in genetic studies. This oversight not only limits our understanding but …
[HTML][HTML] The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective
LM Vaskimo, G Gomon, N Naamane, HJ Cordell… - Genes, 2023 - mdpi.com
Modest effect sizes have limited the clinical applicability of genetic associations with
rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to …
rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to …
The Potential of Genetics in Identifying Women at Lower Risk of Breast Cancer
A Bolze, ET Cirulli, C Hajek, JMS Blitstein… - JAMA …, 2024 - jamanetwork.com
Importance Genetic information is not being used to identify women at lower risk of breast
cancer or other diseases in clinical practice. With the new US Preventive Services Task …
cancer or other diseases in clinical practice. With the new US Preventive Services Task …
Polygenic Risk for Type 2 Diabetes in African Americans
MR Irvin, T Ge, A Patki, V Srinivasasainagendra… - Diabetes, 2024 - Am Diabetes Assoc
African Americans (AAs) have been underrepresented in polygenic risk score (PRS) studies.
Herein, we integrated genome-wide data from multiple observational studies on type 2 …
Herein, we integrated genome-wide data from multiple observational studies on type 2 …
[HTML][HTML] Machine Learning to Advance Human Genome-Wide Association Studies
Machine learning, including deep learning, reinforcement learning, and generative artificial
intelligence are revolutionising every area of our lives when data are made available. With …
intelligence are revolutionising every area of our lives when data are made available. With …