Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

OO Ajani, MT Nlebemuo, JA Adekoya… - Acta …, 2019 - hrcak.srce.hr
Sažetak Surpassing heart diseases, cancer is taking the lead as the deadliest disease
because of its fast rate of spreading in all parts of the world. Tireless commitment to …

Pyridazine (1, 2-diazine): a versatile pharmacophore known for its utility in biological systems

S Sharma - Current Bioactive Compounds, 2024 - benthamdirect.com
The present review describes the biological essence of pyridazine scaffold. Around 142
biologically potential pyridazine entities are gathered in a pile from documented literature …

Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl) quinoxalines, a promising and potent new class of anticancer agents

FAR Rodrigues, IS Bomfim, BC Cavalcanti… - Bioorganic & medicinal …, 2014 - Elsevier
A series of forty-seven quinoxaline derivatives, 2-(XYZC 6 H 2 CHdouble bondN–NH)-
quinoxalines, 1, have been synthesized and evaluated for their activity against four cancer …

An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

B Tanwar, P Purohit, BN Raju, D Kumar, DN Kommi… - RSC Advances, 2015 - pubs.rsc.org
A new synthetic strategy of tandem N-aroylmethylation-nitro reduction–cyclocondensation
has been developed for the first and generalized regioselective synthesis of 2-aryl …

Synthesis of quinoxalines by a carbon nanotube–Gold nanohybrid‐catalyzed cascade reaction of vicinal diols and keto alcohols with diamines

N Shah, E Gravel, DV Jawale, E Doris… - …, 2015 - Wiley Online Library
A one‐pot oxidation–condensation method for the synthesis of quinoxalines from readily
available benzoins or benzhydrols and 1, 2‐phenylenediamines or 2, 3‐diaminopyridine by …

New fluorinated 1, 2-diaminoarenes, quinoxalines, 2, 1, 3-arenothia (selena) diazoles and related compounds

AG Makarov, NY Selikhova, AY Makarov… - Journal of Fluorine …, 2014 - Elsevier
Abstract 5, 6, 7, 8-Tetrafluoroquinoxaline (1) and its previously unknown derivatives (2–8)
were synthesized from glyoxal and polyfluorinated 1, 2-diaminoarenes (10–17) obtained by …

Intermolecular interactions between methanol and some sulphonamide drugs in aqueous medium using thermodynamics approach

I Bahadur, SP Manquthu, LO Olasunkanmi… - Journal of Molecular …, 2019 - Elsevier
Interactions between methanol and some sulphonamide drugs namely sulphamethizole,
sulphabenzamide, sulphaquinoxaline and sulphachloropyridazine were investigated …

Pseudo Jahn–Teller origin of instability of planar configurations of hexa-heterocycles C4N2H4X2 (X= H, F, Cl, Br)

W Hermoso, AR Ilkhani, IB Bersuker - Computational and Theoretical …, 2014 - Elsevier
Symmetry breaking in planar molecular-ring systems in nondegenerate states is due to the
pseudo Jahn–Teller effect (PJTE), and the knowledge of the detailed mechanism of the latter …

Regioselective Suzuki–Miyaura cross-coupling reactions of 2, 6-dichloroquinoxaline

I Ali, B Siyo, Y Al-Soud, A Villinger, P Langer - Synthesis, 2012 - thieme-connect.com
Thieme E-Journals - Synthesis / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNTHESIS Full-text search Full-text search Author …

An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA

V Radulović, M Aleksić… - Journal of the Serbian …, 2012 - farfar.pharmacy.bg.ac.rs
The electrochemical behaviour of a novel nicotinic α4β2 subtype receptor partial agonist
varenicline (VAR), which is used for smoking cessation, was investigated in Britton …