Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Parasitic diseases affect billions of people and are considered a major public health issue.
Close to 400 species are estimated to parasitize humans, of which around 90 are …

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that
the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes …

Infection by helminth parasites is associated with amelioration of allergic reactivity, but
mechanistic insights into this association are lacking. Products secreted by the mouse …

Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …

Heligmosomoides polygyrus (formerly known as Nematospiroides dubius, and also referred
to by some as H. bakeri) is a gastrointestinal helminth that employs multiple …

Hookworms infect more than 700 million people worldwide and cause more morbidity than
most other human parasitic infections. Nippostrongylus brasiliensis (the rat hookworm) has …

The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously
characterised the HpARI protein secreted by the model intestinal nematode …

Root-knot nematodes (RKNs) cause huge agricultural losses every year. They secrete a
repertoire of effectors to facilitate parasitism through the induction of plant-derived giant …

Parasitic helminths reside in immunologically-exposed extracellular locations within their
hosts, yet they are capable of surviving for extended periods. To enable this survival, these …