Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and
treatment responses due to their remarkable plasticity and tumorigenic behaviors. Here, we …

Post-transcriptional control of gene expression is one important mechanism that enables
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …

Introduction Conventionally, vaccines are thought to induce a specific immune response
directed against a target pathogen. Long recognized but poorly understood nonspecific …

Introduction Chronic or uncontrolled activation of myeloid cells including monocytes,
macrophages and dendritic cells (DCs) is a hallmark of immune-mediated inflammatory …

Simple Summary Immunotherapy is designed to stimulate the patient's own immune system
to fight their specific cancer. While immune checkpoint therapies work well for some tumors …

Tumor-associated macrophages (TAM) subtypes have been shown to impact cancer
prognosis and resistance to immunotherapy. However, there is still a lack of systematic …

The mRNA-binding protein KSRP (KH-type splicing regulatory protein) is known to modulate
immune cell functions post-transcriptionally, eg, by reducing the mRNA stability of cytokines …

Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of
tumor immunotherapies such as immune checkpoint blockers, and the efficacy of these …

Background Growing evidence indicates an association between circulating immune cell
phenotypes and idiopathic pulmonary fibrosis (IPF). Although studies have attempted to …

Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant
immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to …