Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape

JD Sheppard, KK Nichols - Ophthalmology and Therapy, 2023 - Springer
Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of
evaporative dry eye disease (DED). MGD is characterized by a reduction in meibum …

The role of sphingolipids in meibomian gland dysfunction and ocular surface inflammation

V Paranjpe, A Galor, R Grambergs, N Mandal - The ocular surface, 2022 - Elsevier
Inflammation occurs in response to tissue injury and invasion of microorganisms and is
carried out by the innate and adaptive immune systems, which are regulated by numerous …

[HTML][HTML] Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure

H Zhang, L Lu, C Zhao, Q Liu, Q Zhou, Y Zhang… - Environment …, 2022 - Elsevier
Health risks caused by crucial environmental carcinogens N-nitrosamines triggered
ubiquitous attention. As the liver exerted vital function through metabolic process, lipid …

[HTML][HTML] Relationship between human meibum lipid composition and the severity of meibomian gland dysfunction: a spectroscopic analysis

S Nagar, L Ajouz, KK Nichols, S Kumar… - … & Visual Science, 2023 - tvst.arvojournals.org
Purpose: Information on the relationship between meibum lipid composition and severity of
meibomian gland dysfunction (MGD) is limited. The purpose of this study was to analyze the …

Relationships between ocular surface sphingomyelinases, Meibum and Tear Sphingolipids, and clinical parameters of meibomian gland dysfunction

V Sanchez, A Galor, K Jensen, K Mondal, N Mandal - The ocular surface, 2022 - Elsevier
Purpose Sphingolipids (SPL) are a class of lipid molecules that play important functional
and structural roles in our body and are a component of meibum. Sphingomyelinases …

Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross‐Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface …

JM Serrano-Morales… - Journal of …, 2024 - Wiley Online Library
Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED),
as well as its influence on tear film and meibomian glands. Methods. This cross‐sectional …

Meibum Lipidomic Analysis in Evaporative Dry Eye Subjects

J Garcia-Queiruga, H Pena-Verdeal… - International Journal of …, 2024 - mdpi.com
Meibomian Glands (MG) are sebaceous glands responsible for the production of meibum,
the main component of the Tear Film Lipid Layer (TFLL). The TFLL facilitates the spread of …

Urea and ocular surface: Synthesis, secretion and its role in tear film homeostasis

S Singh, CM Hammer, F Paulsen - The Ocular Surface, 2023 - Elsevier
Urea has been detected in the tear film, aqueous humor, and vitreous of the eye. While most
of the urea in the aqueous humor and vitreous is considered to be an ultrafiltrate from the …

Candidate molecular compounds as potential indicators for meibomian gland dysfunction

K Asiedu - Frontiers in Medicine, 2022 - frontiersin.org
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease throughout the
world. Studies have shown that several molecules in meibum, including but not limited to …

Efficacy of meibomian gland expression combined with Home-Based therapy in the management of dry eye Disease: A systematic review and Meta-Analysis

A Ballesteros-Sánchez, JM Sánchez-González… - Contact Lens and …, 2023 - Elsevier
Purpose To compare the effectiveness of meibomian gland expression (MGX) combined
with home-based therapy versus home-based therapy alone for the treatment of dry eye …