During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

Fibroblast growth factor (FGF) signalling has been implicated during several phases of early
embryogenesis, including the patterning of the embryonic axes, the induction and/or …

Biased left-right asymmetry is a fascinating and medically important phenomenon. We
provide molecular genetic and physiological characterization of a novel, conserved, early …

Cilia are cell surface organelles found on most epithelia in vertebrates. Specialized groups
of cilia have critical roles in embryonic development, including left–right axis formation …

In the mouse embryo, the splanchnic mesodermal cells of the anterior heart field (AHF)
migrate from the pharynx to contribute to the early myocardium of the outflow tract (OT) and …

Bone is a metabolically active organ that undergoes continuous remodeling throughout life.
However, many complex skeletal defects such as large traumatic bone defects or extensive …

The vertebrate head is an extremely complicated structure: development of the head
requires tissue–tissue interactions between derivates of all the germ layers and coordinated …

Fibroblast growth factors (FGFs) comprise a large family of growth factors, regulating diverse
biological processes including cell proliferation, migration, and differentiation. Each FGF …

Background: Embryonic development can often adjust its morphogenetic processes to
counteract external perturbation. The existence of self‐monitoring responses during pattern …

Transforming growth factor beta (TGF-β) proteins play important roles in morphogenesis of
many craniofacial tissues; however, detailed biological mechanisms of TGF-β action …