Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …

The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl
(P2)/N-methylpiperazin-1-yl (P3)] methyl)-1 H-indole-2, 3-dione) moieties against human (h) …

The Mannich reaction is one of the most important types of organic chemistry fundamental
reactions. It is a crucial stage in the production of various medicines, natural goods, and …

Background: Mannich bases are an important compounds in medicinal chemistry. They
have wide range of biological activities including carbonic anhydrase (CA) inhibitory and …

In this study, new Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substitutedpiperazin-1-yl)
methyl) benzylidene)-2, 3-dihydro-1H-inden-1-one (1, 2, 4, 5, 8), 2-(3-((substituted) …

(4-Fluorophenyl)-1-propanone) has been extensively investigated in this work due to its
significant theoretical and experimental interest and potential pharmacological implications …

Abstract A series of 2-(arylidene)-1-(4-chlorophenyl)-4, 4, 4-trifluorobutane-1, 3-diones (2–
4), 4-(arylidene)-3-(4-chlorophenyl)-5-(trifluoromethyl)-4 H-pyrazoles (5–7), 1-(4 …

Chalcones and Mannich bases are bioactive compounds and known with their cytotoxicities.
α, β-Unsaturated ketones are reported with their alkylating potential to cellular thiols thereby …

In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-
methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their …

New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-
(aminomethyl)-4-(1 H-benzimidazol-2-yl) phenol and 2, 6-bis (aminomethyl)-4-(1 H …