Chronic wasting disease: a cervid prion infection looming to spillover

A Otero, CD Velásquez, J Aiken, D McKenzie - Veterinary Research, 2021 - Springer
The spread of chronic wasting disease (CWD) during the last six decades has resulted in
cervid populations of North America where CWD has become enzootic. This insidious …

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

K Moazami-Goudarzi, O Andréoletti, JL Vilotte… - Veterinary …, 2021 - Springer
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting
several captive, free ranging and wild cervid species. Responsible for marked population …

Experimental transmission of the chronic wasting disease agent to swine after oral or intracranial inoculation

SJ Moore, MH West Greenlee, N Kondru… - Journal of …, 2017 - Am Soc Microbiol
Chronic wasting disease (CWD) is a naturally occurring, fatal neurodegenerative disease of
cervids. The potential for swine to serve as hosts for the agent of CWD is unknown. The …

North American and Norwegian chronic wasting disease prions exhibit different potential for interspecies transmission and zoonotic risk

S Pritzkow, D Gorski, F Ramirez… - The Journal of …, 2022 - academic.oup.com
Background Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting
various species of wild and captive cervids. The risk that CWD poses to cohabiting animals …

The transmissible spongiform encephalopathies of livestock

JJ Greenlee, MHW Greenlee - ILAR journal, 2015 - academic.oup.com
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal protein-
misfolding neurodegenerative diseases. TSEs have been described in several species …

Chronic wasting disease (CWD) in cervids and the consequences of a mutable protein conformation

CJ Silva - ACS omega, 2022 - ACS Publications
Chronic wasting disease (CWD) is a prion disease of cervids (deer, elk, moose, etc.). It
spreads readily from CWD-contaminated environments and among wild cervids. As of 2022 …

Transmission, strain diversity, and zoonotic potential of chronic wasting disease

S Pritzkow - Viruses, 2022 - mdpi.com
Chronic wasting disease (CWD) is a prion disease affecting several species of captive and
free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably …

Selective Breeding for Disease-Resistant PRNP Variants to Manage Chronic Wasting Disease in Farmed Whitetail Deer

N Haley, R Donner, K Merrett, M Miller, K Senior - Genes, 2021 - mdpi.com
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy (TSE) of
cervids caused by a misfolded variant of the normal cellular prion protein, and it is closely …

Successful transmission of the chronic wasting disease (CWD) agent to white-tailed deer by intravenous blood transfusion

N Mammadova, E Cassmann, JJ Greenlee - Research in Veterinary …, 2020 - Elsevier
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSEs) that
affects free-ranging and captive cervid species. The infectious agent of CWD may be …

An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development

N Kondru, S Manne, R Kokemuller, J Greenlee… - Scientific reports, 2020 - nature.com
Chronic wasting disease (CWD) is a rapidly spreading prion disease of cervids, yet
antemortem diagnosis, treatment, and control remain elusive. We recently developed an …