PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

(1) Background: Over the past 10 years, a number of scientific studies have demonstrated
the therapeutic potential of cannabinoid compounds present in the Cannabis Sativa and …

Impaired mitochondrial structure and function are common features of neurodegenerative
disorders, ultimately characterized by the death of neural cells promoted by still unknown …

Abstract Bv8/prokineticin 2 (PK2) is a member of a bioactive family of peptides that regulate
multiple functions in the CNS including hyperalgesia, neurogenesis, neuronal survival and …

Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological
conditions, including cerebral ischemia. However, the capability of PBM for ischemic stroke …

Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death
induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia …

Poly (ADP-ribosyl) ation (PARylation) is a posttranslational protein modification catalyzed by
members of the poly (ADP-ribose) polymerase (PARP) enzyme family. PARylation regulates …

The complexity of microglia phenotypes and their related functions compels the continuous
study of microglia in diseases animal models. We demonstrated that oxygen-glucose …

Epilepsy is a central nervous system (CNS) disorder causing repeated seizures due to a
transient excessive or synchronous alteration in the electrical activity of the brain. Several …

Long-term alcohol use can lead to alterations in brain structure and functions and, in some
cases, to neurodegeneration. Several mechanisms have been proposed to explain ethanol …