Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Recent clinical studies indicate a strong link between AKI and progression of CKD. The
increasing prevalence of AKI must compel the nephrology community to consider the long …

The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans
and animal models with chronic kidney disease, renal GCGR expression is reduced …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

Renal tubulointerstitial damage is the final common pathway leading from chronic kidney
disease to end-stage renal disease. Inflammation is clearly involved in tubulointerstitial …

In humans, a number of genetic factors have been linked to the development of fibrosis in a
variety of different organs. Seeking a wider understanding of this observation in man is …

Preclinical animal models of chronic kidney disease (CKD) are critical to investigate the
underlying mechanisms of disease and to evaluate the efficacy of novel therapeutics aimed …

Animal models of chronic kidney disease (CKD) are important experimental tools that are
used to investigate novel mechanistic pathways and to validate potential new therapeutic …

Chronic kidney disease constitutes an increasing medical burden affecting 26 million people
in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological …