Designing cancer immunotherapies that engage T cells and NK cells
O Kyrysyuk, KW Wucherpfennig - Annual review of immunology, 2023 - annualreviews.org
T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
DG Pellicci, HF Koay, SP Berzins - Nature Reviews Immunology, 2020 - nature.com
T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
T cells are critical effectors of cancer immunotherapies, but little is known about their gene
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing …
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
The prognostic landscape of genes and infiltrating immune cells across human cancers
Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …
Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn's disease
Background & Aims Studies are needed to determine the mechanisms of mucosal
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …
MAIT cells are activated during human viral infections
B Van Wilgenburg, I Scherwitzl, EC Hutchinson… - Nature …, 2016 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …