Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on
major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by …

Dendritic cells have the ability to efficiently present internalized antigens on major
histocompatibility complex (MHC) I molecules. This process is termed cross-presentation …

Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …

It is well understood that antigen-presenting cells (APCs) within tumors typically do not
maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse …

Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …