Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

Hyperuricemia may occur when there is an excess of uric acid in the blood. Hyperuricemia
may result from increased production or decreased excretion of uric acid. Elevated uric acid …

Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …

Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA)
metabolism, which is a complex physiological process involving multiple organs (liver …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic
homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis …

More than 2 million people in the United States have myalgic encephalomyelitis/chronic
fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain …

Objective—Serum uric acid (UA) has been associated with increased risk of cardiovascular
and metabolic diseases. However, the causal mechanisms linking elevated UA levels to …

Hyperuricemia, has been traditionally related to nephrolithiasis and gout. However, it has
also been associated with the development of type 2 diabetes mellitus (T2DM) and …

Simple Summary The concentration of uric acid in blood is sex-, age-and diet-dependent
and is maintained close to its maximal solubility, indicating that it plays some important role …