Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

Recent advances in our understanding of the structure-function relationship of motile cilia
with the 9+ 2 microtubular arrangement have helped explain some of the mechanisms of …

Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse
set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx …

Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4)
channel depends on phospholipase A2 (PLA2) activation and the subsequent production of …

Chronic rhinosinusitis (CRS), affecting more than 35 million Americans of all ages, 1
represents several distinct entities which are clinically indistinguishable. Although the …

Cilia are cell organelles that play important roles in cell motility, sensory and developmental
functions and are involved in a range of human diseases, known as ciliopathies. Here, we …

There are multiple roles for purinergic signalling in both male and female reproductive
organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves …

This article's objectives are to investigate the relationship between adenosine triphosphate
(ATP) production (oxidative phosphorylation and glycolysis) and fertility of bovine …

Abstract The inositol-1, 4, 5-trisphosphate receptors (InsP 3 Rs) are the major intracellular
Ca 2+-release channels in cells. Activity of InsP 3 Rs is essential for elementary and global …

Background Dynamic regulation of respiratory ciliary beat frequency (CBF) is regulated by
fluxes in intracellular calcium (Ca2+). P2X receptors (P2XR) are extracellular ATP-gated …