Depression, anxiety, and apathy in mild cognitive impairment: current perspectives

L Ma - Frontiers in aging neuroscience, 2020 - frontiersin.org
Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly
Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed …

Apathy associated with neurocognitive disorders: recent progress and future directions

KL Lanctôt, L Agüera-Ortiz, H Brodaty, PT Francis… - Alzheimer's & …, 2017 - Elsevier
Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's
disease and mild cognitive impairment. Although the definition of apathy is inconsistent in …

Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on …

RA Sperling, PS Aisen, LA Beckett, DA Bennett… - Alzheimer's & …, 2011 - Elsevier
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

Diagnostic criteria for apathy in neurocognitive disorders

DS Miller, P Robert, L Ereshefsky, L Adler… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Apathy is common in neurocognitive disorders (NCD) but NCD‐specific
diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials …

Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders

P Robert, CU Onyike, AFG Leentjens… - European …, 2009 - cambridge.org
There is wide acknowledgement that apathy is an important behavioural syndrome in
Alzheimer's disease and in various neuropsychiatric disorders. In light of recent research …

Management of behavioral problems in Alzheimer's disease

S Gauthier, J Cummings, C Ballard… - International …, 2010 - cambridge.org
Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has
effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse …

Neuropathologic correlates of psychiatric symptoms in Alzheimer's disease

AJ Ehrenberg, CK Suemoto… - Journal of …, 2018 - content.iospress.com
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease
(AD)-related pathology may open avenues for effective treatments. Here, we investigate the …

Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment‐related aspects of apathy from depression in …

KL Lanctôt, Z Ismail, KK Bawa… - … journal of geriatric …, 2023 - Wiley Online Library
Objectives This narrative review describes the clinical features of apathy and depression in
individuals with neurocognitive disorders (NCDs), with the goal of differentiating the two …

Functional impairment in elderly patients with mild cognitive impairment and mild Alzheimer disease

PJ Brown, DP Devanand, X Liu… - Archives of general …, 2011 - jamanetwork.com
Context The original mild cognitive impairment (MCI) criteria exclude substantial functional
deficits, but recent reports suggest otherwise. Identifying the extent, severity, type, and …

Are the available apathy measures reliable and valid? A review of the psychometric evidence

DE Clarke, JY Ko, EA Kuhl, R van Reekum… - Journal of …, 2011 - Elsevier
OBJECTIVE: Apathy is highly prevalent among neuropsychiatric populations and is
associated with greater morbidity and worse functional outcomes. Despite this, it remains …