Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …
and influence cellular function via effects on membrane properties, and also by acting as a …
The isoprostanes—25 years later
Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …
[HTML][HTML] Oxygen and oxidative stress in the perinatal period
I Torres-Cuevas, A Parra-Llorca, A Sánchez-Illana… - Redox biology, 2017 - Elsevier
Fetal life evolves in a hypoxic environment. Changes in the oxygen content in utero caused
by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the …
by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the …
Isoprostane generation and function
Free radicals derived primarily from molecular oxygen have been implicated in a variety of
human disorders including atherosclerosis, cancer, neurodegenerative diseases, and aging …
human disorders including atherosclerosis, cancer, neurodegenerative diseases, and aging …
Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids
E Kansanen, HK Jyrkkänen, AL Levonen - Free Radical Biology and …, 2012 - Elsevier
Unsaturated fatty acids are prone to radical reactions that occur in biological situations
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …
Mechanisms of the acute effects of inhaled ozone in humans
PA Bromberg - Biochimica et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Ambient air ozone (O 3) is generated photochemically from oxides of nitrogen and volatile
hydrocarbons. Inhaled O 3 causes remarkably reversible acute lung function changes and …
hydrocarbons. Inhaled O 3 causes remarkably reversible acute lung function changes and …
Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane‐mediated thromboxane A2 receptor activation
Isoprostanes are free radical‐catalysed PG‐like products of unsaturated fatty acids, such as
arachidonic acid, which are widely recognized as reliable markers of systemic lipid …
arachidonic acid, which are widely recognized as reliable markers of systemic lipid …
Isoprostanes and neuroprostanes as biomarkers of oxidative stress in neurodegenerative diseases
E Miller, A Morel, L Saso, J Saluk - Oxidative Medicine and …, 2014 - Wiley Online Library
Accumulating data shows that oxidative stress plays a crucial role in neurodegenerative
disorders. The literature data indicate that in vivo or postmortem cerebrospinal fluid and …
disorders. The literature data indicate that in vivo or postmortem cerebrospinal fluid and …
Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids
M Delmastro-Greenwood, BA Freeman… - Annual review of …, 2014 - annualreviews.org
Unsaturated fatty acids are metabolized to reactive products that can act as pro-or anti-
inflammatory signaling mediators. Electrophilic fatty acid species, including nitro-and oxo …
inflammatory signaling mediators. Electrophilic fatty acid species, including nitro-and oxo …
Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration
ME Figueiredo-Pereira, P Rockwell… - Frontiers in molecular …, 2015 - frontiersin.org
The immune response of the CNS is a defense mechanism activated upon injury to initiate
repair mechanisms while chronic over-activation of the CNS immune system (termed …
repair mechanisms while chronic over-activation of the CNS immune system (termed …