Macrophages and the maintenance of homeostasis

DM Mosser, K Hamidzadeh, R Goncalves - Cellular & molecular …, 2021 - nature.com
There have been many chapters written about macrophage polarization. These chapters
generally focus on the role of macrophages in orchestrating immune responses by …

[HTML][HTML] Specialized pro-resolving mediators: endogenous regulators of infection and inflammation

MC Basil, BD Levy - Nature Reviews Immunology, 2016 - nature.com
Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Lipid mediator class switching during acute inflammation: signals in resolution

BD Levy, CB Clish, B Schmidt, K Gronert… - Nature …, 2001 - nature.com
Abstract Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas
lipoxins (LXs) have unique anti-inflammatory actions. Temporal analyses of these …

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

CN Serhan - Annu. Rev. Immunol., 2007 - annualreviews.org
Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …

Key mechanisms governing resolution of lung inflammation

CT Robb, KH Regan, DA Dorward, AG Rossi - Seminars in …, 2016 - Springer
Innate immunity normally provides excellent defence against invading microorganisms.
Acute inflammation is a form of innate immune defence and represents one of the primary …

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

J Claria, CN Serhan - … of the National Academy of Sciences, 1995 - National Acad Sciences
Aspirin [acetylsalicylic acid (ASA)], along with its analgesic-antipyretic uses, is now also
being considered for cardiovascular protection and treatments in cancer and human …

Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases

TE Van Dyke, CN Serhan - Journal of dental research, 2003 - journals.sagepub.com
The periodontal diseases are infectious diseases caused by predominantly Gram-negative
bacteria. However, as our understanding of the pathogenesis of the periodontal diseases …

Resolution of acute inflammation in the lung

BD Levy, CN Serhan - Annual review of physiology, 2014 - annualreviews.org
Acute inflammation in the lung is essential to health. So too is its resolution. In response to
invading microbes, noxious stimuli, or tissue injury, an acute inflammatory response is …

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

M Romano, E Cianci, F Simiele, A Recchiuti - European journal of …, 2015 - Elsevier
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

CN Serhan - Prostaglandins, leukotrienes and essential fatty acids, 2005 - Elsevier
Lipoxins (LXs) or the lipoxygenase interaction products are generated from arachidonic acid
via sequential actions of lipoxygenases and subsequent reactions to give specific …