Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

microRNA-based biomarkers in Alzheimer's disease (AD)

Y Zhao, V Jaber, PN Alexandrov, A Vergallo… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized
by complex pathophysiological dynamics taking place at multiple biological levels, including …

Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets

P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

MicroRNAs in Alzheimer's disease: function and potential applications as diagnostic biomarkers

W Wei, ZY Wang, LN Ma, TT Zhang, Y Cao… - Frontiers in molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. Although the incidence of
AD is high, the rates of diagnosis and treatment are relatively low. Moreover, effective means …

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

J Diniz Pereira, V Gomes Fraga… - Journal of …, 2021 - Wiley Online Library
Similar to dementia, the risk for developing type 2 diabetes mellitus (T2DM) increases with
age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD) …

Omics-based biomarkers discovery for Alzheimer's disease

Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …

Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease

M Xi, T Sun, S Chai, M Xie, S Chen, L Deng… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), one of the greatest threats to human health, is
characterized by declined cognition and changed behavior. Cyclic adenosine …

A metabolite panel that differentiates Alzheimer's disease from other dementia types

L Jia, J Yang, M Zhu, Y Pang, Q Wang… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Alzheimer's disease (AD) is associated with altered metabolites. This study
aimed to determine the validity of using circulating metabolites to differentiate AD from other …

Climate change and cetacean health: impacts and future directions

A Kebke, F Samarra, D Derous - … Transactions of the …, 2022 - royalsocietypublishing.org
Climate change directly impacts the foraging opportunities of cetaceans (eg lower prey
availability), leads to habitat loss, and forces cetaceans to move to other feeding grounds …

New approach for early and specific Alzheimer disease diagnosis from different plasma biomarkers

A Forte, S Lara, C Peña-Bautista, M Baquero… - Clinica Chimica …, 2024 - Elsevier
Abstract Background Alzheimer Disease (AD) is a complex pathology, in which several
biochemical pathways could be involved. Therefore, the development of clinical studies …