• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Inherited Cardiomyopathies | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Kardiomiopatie definiuje się jako strukturalne oraz funkcjonalne nieprawidłowości mięśnia
komór, które nie wynikają z niedokrwienia na skutek choroby wieńcowej czy …

1From Mayo Clinic, Rochester, Minnesota; 2Fondazione Salvatore Maugeri University of
Pavia, Pavia, Italy and New York University, New York, New York; 3University Hospital …

Purpose: Hypertrophic cardiomyopathy (HCM) is caused primarily by pathogenic variants in
genes encoding sarcomere proteins. We report genetic testing results for HCM in 2,912 …

Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Genetic studies in the 1980s and 1990s led to landmark discoveries that sarcomere
mutations cause both hypertrophic and dilated cardiomyopathies. Sarcomere mutations also …

This review provides an historical and personal perspective on the discovery of genetic
causes for hypertrophic cardiomyopathy (HCM). Extraordinary insights by physicians who …

Lamins A and C are intermediate filament nuclear envelope proteins encoded by the LMNA
gene. Mutations in LMNA cause autosomal dominant severe heart disease, accounting for …

Aims Despite our increased understanding of the genetic basis of dilated cardiomyopathy
(DCM), the clinical utility and yield of clinically meaningful findings of comprehensive next …