Neurodegenerative diseases (NDs) are severe disorders of the nervous system, and their
causes are still not completely understood. Modeling the complex pathological mechanisms …

Beyond the encouraging results and broad clinical applicability of immune checkpoint (ICP)
inhibitors in cancer therapy, ICP-based immunotherapies in the context of autoimmune …

An altered immune response has been identified as a pathophysiological factor in
Parkinson's disease (PD). We aimed to identify blood immunity-associated proteins that …

Alzheimer's disease (AD) that is an important contributor to dementia, is a chronic and
irreversible neurodegenerative disease, with high rates of disability and mortality. Recently …

Tuberculosis (TB) was the leading cause of death from a single infectious agent before the
coronavirus pandemic. Therefore, it is important to search for severity biomarkers and devise …

Defective T‐cell functions play a role in the persistence of HCV infection. Activated T cells
express CD137, which costimulates antivirus T‐cell responses, and this activity is …

Diabetic cognitive impairment (DCI) is a central nervous system complication induced by
peripheral metabolic dysfunction of diabetes mellitus. Cumulative studies have shown that …

B lymphocytes are immune cells studied predominantly in the context of peripheral humoral
immune responses against pathogens. Evidence has been accumulating in recent years on …

Aberrant expression of the proto‐oncogene BCL6 is a driver of tumorigenesis in diffuse
large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell‐specific …

T cell depletion and functional impairment are characteristics of sepsis. CD137 is a
costimulatory receptor on activated T cells, while soluble CD137 (sCD137) inhibits CD137 …