Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the
cellular uptake of iron and in the regulation of cell growth. Iron uptake occurs via the …

The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to
mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from …

The mortality rates from various tumor types can be reduced dramatically by use of highly
active drugs. This is particularly true for platinum-based drugs, being among the most …

Most of the iron in a mammalian body is complexed with various proteins. Moreover, in
response to infection, iron availability is reduced in both extracellular and intracellular …

With the discovery that transferrin serves as the iron source for hemoglobin-synthesizing
immature red blood cells came the demonstration that a cell surface receptor, now known as …

Despite its abundance in the earth's crust, iron deficiency is a serious health issue in many
parts of the world. Although fundamental observations about iron metabolism and the …