Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

By 1980, it was thought that we already knew most of the major mechanisms regulating
vascular tone. However, after the somewhat serendipity discovery that endothelium is …

Heart failure (HF) is a major cause of morbidity and mortality with more than 5.1 million
individuals affected in the USA. Ventricular tachyarrhythmias (VAs) including ventricular …

Prior research has suggested that GATA6+ pericardial macrophages may traffic to the
myocardium to prevent interstitial fibrosis after myocardial infarction (MI), while subsequent …

The remote but heart-encircling location of pericardial fluid confers this biofluid unique
properties. Once past the limitation of the invasive collection, for instance, on occasion of …

Sudden cardiac death (SCD), most often induced by ventricular arrhythmias, is one of the
main reasons for cardiovascular-related mortality. While coronary artery disease remains the …

Abstract Endothelin-1 (ET-1), the predominant isoform of the ET peptide family and a potent
vasoconstrictor, has been shown to aggravate ischemia-induced ventricular arrhythmias …

Cardiac Cellular Electrophysiology is intended for the clinical cardiologist who wishes to
refresh or deepen his understanding of the cellular basis of cardiac electrophysiology, for …

Abstract Objective: Endothelin-1 (ET-1) production increases during acute myocardial
infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and …