Pluripotent stem cells (PSCs) are a potential replacement tissue source for degenerative
diseases. Age-related macular degeneration (AMD) is a blinding disease triggered by …

Cell-based therapeutics offer diverse options for treating retinal degenerative diseases, such
as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). AMD is …

Background Human pluripotent stem cells (hPSCs) provide a promising cell source for
ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture …

Retinal pigment epithelial (RPE) cells have several functions, including support of the neural
retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly …

Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells could serve
as a replacement therapy in advanced stages of age-related macular degeneration …

Human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells could
replace lost tissue in geographic atrophy (GA) but efficacy has yet to be demonstrated in a …

Dysfunction or death of retinal pigment epithelial (RPE) cells is involved in some forms of
Retinitis Pigmentosa and in age-related macular degeneration (AMD). Since there is no cure …

Blinding disorders of the outer retina involve dysfunction and degeneration of
photoreceptors. One potential approach to treat these forms of blindness is to repopulate the …

We describe a robust method to direct the differentiation of pluripotent stem cells into retinal
pigment epithelial cells (RPE). The purpose of providing a detailed and thorough protocol is …

Age-related macular degeneration (AMD), a leading cause of blindness, is characterized by
the death of the retinal pigmented epithelium (RPE), which is a monolayer posterior to the …