Noncoding RNAs (ncRNAs) represent a large segment of the human transcriptome and
have been shown to play important roles in cellular physiology and disease pathogenesis …

The interplay between abnormalities in genes coding for proteins and noncoding
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …

Small non-coding microRNAs (miRNAs) are epigenetic regulators that target specific cellular
mRNA to modulate gene expression patterns and cellular signaling pathways. miRNAs are …

Nucleocytoplasmic trafficking of proteins/RNAs is essential to normal cellular function.
Indeed, accumulating evidence suggests that cancer cells escape anti-neoplastic …

Abstract Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor
p53, has been gaining increasing interest as a strategy for the treatment of acute myeloid …

Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem
or progenitor cells and displays the most frequent acute leukemia in adults. Although some …

Deregulation of microRNAs' expression frequently occurs in acute myeloid leukemia (AML).
Lower miR-181a expression is associated with worse outcomes, but the exact mechanisms …

Chlamydia trachomatis genital infection in women causes serious adverse reproductive
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …

MicroRNAs (miRs) have been demonstrated to perform important roles in normal
hematopoiesis and leukemogenesis. Accumulating evidence suggests that miR‑10a and …

APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway
of DNA lesions and in the transcriptional regulation of genes involved in tumor progression …