Covering: up to the end of August 2007 The purpose of diversity-oriented synthesis is to
drive the discovery of small molecules with previously unknown biological functions. Natural …

First isolated in the late 1960s from microalgae of theOchromonas species, the
chlorosulfolipids were largely considered as intractable synthetic challenges until recently …

A concise and convergent total synthesis of the highly cytotoxic marine natural products
iejimalide A− D (1− 4) is reported, which relies on an effective ring-closing metathesis (RCM) …

Strategic positioning of a silyl group on the diene unit of a diene-ene substrate allows
rigorous regio-and stereocontrol to be exerted during metathesis-based macrocyclization …

Transannular chemical reactions are unparalleled in their ability to generate high degrees of
stereochemical and architectural complexity in a single transformation. However, the …

The enantioselective total synthesis of (+)-hexachlorosulfolipid, a cytotoxin found in the
Adriatic mussel Mytilus galloprovincialis, is described. The unique chlorinated hydrocarbon …

Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results
in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this …

A convergent total synthesis of the antibiotic macrolide myxovirescin A1 (1) is described that
is largely based on reagent‐and catalyst‐controlled transformations. This includes a highly …

Asymmetric total syntheses of nannocystins A and A0 were achieved in a convergent route
starting from simple materials. Nannocystin family natural products bear potent anticancer …

Synthesis of the JKLMN-ring fragment of Caribbean ciguatoxin C-CTX-1, the causative toxin
of ciguatera fish poisoning in the Caribbean Sea and the Northeast Atlantic areas, is …