Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related …
KD Rainsford, AL Parke, M Clifford-Rashotte… - …, 2015 - Springer
Objectives This review examines the pharmacokinetics, modes of action and therapeutic
properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in …
properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in …
Antimalarial drug toxicity: a review
WRJ Taylor, NJ White - Drug safety, 2004 - Springer
Malaria, caused mostly by Plasmodium falciparum and P. vivax, remains one of the most
important infectious diseases in the world. Antimalarial drug toxicity is one side of the risk …
important infectious diseases in the world. Antimalarial drug toxicity is one side of the risk …
Clinical pharmacokinetics and metabolism of chloroquine: focus on recent advancements
J Ducharme, R Farinotti - Clinical pharmacokinetics, 1996 - Springer
This paper presents the current state of knowledge on chloroquine disposition, with special
emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the …
emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the …
Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases
DE Furst - Lupus, 1996 - journals.sagepub.com
Hydroxychloroquine (HCQ) and chloroquine (CQ) are well absorbed (0.7-0.8 bioavailability)
when given orally. Severe malnutrition (such as kwashiorkor) effects absorption but diahrrea …
when given orally. Severe malnutrition (such as kwashiorkor) effects absorption but diahrrea …
Pharmacokinetics of quinine, chloroquine and amodiaquine: clinical implications
Malaria is associated with a reduction in the systemic clearance and apparent volume of
distribution of the cinchona alkaloids; this reduction is proportional to the disease severity …
distribution of the cinchona alkaloids; this reduction is proportional to the disease severity …
Drugs in human milk: clinical pharmacokinetic considerations
HC Atkinson, EJ Begg, BA Darlow - Clinical pharmacokinetics, 1988 - Springer
Drugs ingested by a lactating mother would be expected to appear in human milk to some
extent and be ingested by a breast-feeding infant. Drugs pass from maternal plasma into …
extent and be ingested by a breast-feeding infant. Drugs pass from maternal plasma into …
Principles of drug biodisposition in the neonate: a critical evaluation of the pharmacokinetic-pharmacodynamic interface (part I)
JB Besunder, MD Reed, JL Blumer - Clinical pharmacokinetics, 1988 - Springer
Rational pharmacotherapy is dependent upon an understanding of the clinical
pharmacokinetic and pharmacodynamic properties of the drugs employed. Although the …
pharmacokinetic and pharmacodynamic properties of the drugs employed. Although the …
Pharmacokinetics and pharmacological properties of chloroquine and hydroxychloroquine in the context of COVID‐19 infection
Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria. To
date, these medications are not approved for the treatment of viral infections, and there are …
date, these medications are not approved for the treatment of viral infections, and there are …
Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria
At present, artemether/lumefantrine (AL) is the only fixed-dose artemisinin-based
combination therapy recommended and pre-qualified by WHO for the treatment of …
combination therapy recommended and pre-qualified by WHO for the treatment of …
A systematic review on maternal-to-infant transfer of drugs through breast milk during the treatment of malaria, tuberculosis, and neglected tropical diseases
Background Exclusive breastfeeding of infants under 6 months of age is recommended by
the World Health Organization. In 2021, over 300 million combined incident cases of …
the World Health Organization. In 2021, over 300 million combined incident cases of …