Panic disorder is a common mental disorder that affects up to 5% of the population at some
point in life. It is often disabling, especially when complicated by agoraphobia, and is …

Neurotrophins are critical to the development and maintenance of the mammalian central
nervous system. Among them is brain‐derived neurotrophic factor (BDNF), whose synthesis …

Tobacco use is a leading contributor to disability and death worldwide, and genetic factors
contribute in part to the development of nicotine dependence. To identify novel genes for …

Molecular genetic studies of personality began with two high impact papers in 1996 that
showed provisional associations between the dopamine DRD4 exon III repeat region and …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

The contribution of common genetic variation to one or more established smoking behaviors
was investigated in a joint analysis of two genome wide association studies (GWAS) …

Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615
subjects in 632 families [319 African-American (AA) and 313 European-American (EA)] …

Aims To extend the previously identified association between a single nucleotide
polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha‐5 (CHRNA5) and …

Despite almost two decades of intensive tobacco-control efforts, approximately 23% of
American adults continue to smoke, and 13% are nicotine-dependent. Cigarette smoking is …

Background Classical genetic studies indicate that nicotine dependence is a substantially
heritable complex disorder. Genetic vulnerabilities to nicotine dependence largely overlap …