Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Abstract Collagen alpha-1 (III) chain, also known as the alpha 1 chain of type III collagen, is
a protein that in humans is encoded by the COL3A1 gene. Three alpha 1 chains are …

Nature uses elaborate methods to control protein assembly, including that of heterotrimeric
collagen. Here, we established design principles for the composition and register-selective …

Introduction: Enzymatic cross-linking of the collagens within the extracellular matrix (ECM)
catalyzed by enzymes such as lysyl oxidase (LOX) and lysyl oxidase like-enzymes 1–4 …

Since their first synthesis in the late 1960s, collagen mimetic peptides (CMPs) have been
used as a molecular tool to study collagen, and as an approach to develop novel collagen …

Collagens are the foundational component of diverse tissues, including skin, bone, cartilage,
and basement membranes, and are the most abundant protein class in animals. The fibrillar …

The formation of amorphous misfolded and aggregated proteins is a hallmark of proteome
stress in diseased cells. Given its lack of defined targeting sites, the rational design of …

Changes in the oxidative (redox) environment accompany idiopathic pulmonary fibrosis
(IPF). S-glutathionylation of reactive protein cysteines is a post-translational event that …

Triple helix formation of procollagen occurs in the endoplasmic reticulum (ER) where the
single-stranded α-chains of procollagen undergo extensive post-translational modifications …

Collagen is the most abundant protein in mammals. A unique feature of collagen is its triple-
helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen …