[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death

CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

The role of exosomes and exosomal microRNA in cardiovascular disease

D Zheng, M Huo, B Li, W Wang, H Piao… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane
bilayer, secreted by most cells in the body. They carry various molecules, including proteins …

Emergence of the stem cell secretome in regenerative engineering

L Daneshmandi, S Shah, T Jafari, M Bhattacharjee… - Trends in …, 2020 - cell.com
The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …

Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …

The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

M Ghafourian, R Mahdavi, Z Akbari Jonoush… - Cell Communication and …, 2022 - Springer
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

Molecular mechanisms of cardiomyocyte death in drug-induced cardiotoxicity

W Ma, S Wei, B Zhang, W Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal
physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases …

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles

SM Davidson, CM Boulanger, E Aikawa… - Cardiovascular …, 2023 - academic.oup.com
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from
cells of the cardiovascular system, and are considered important mediators of intercellular …

Crosstalk between oxidative stress and exosomes

W Zhang, R Liu, Y Chen, M Wang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Mammals have several organs comprising various cells with different functions.
Furthermore, eukaryotic cells are compartmentalized into functionally distinct organelles …

Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Y Xiong, R Tang, J Xu, W Jiang, Z Gong… - Stem cell research & …, 2022 - Springer
Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem cells
(MSCs), have shown attractive application prospects in acute myocardial infarction (AMI) …

[HTML][HTML] Role of oxidative stress and inflammation in doxorubicin-induced cardiotoxicity: A brief account

R Vitale, S Marzocco, A Popolo - International Journal of Molecular …, 2024 - mdpi.com
Cardiotoxicity is the main side effect of several chemotherapeutic drugs. Doxorubicin (Doxo)
is one of the most used anthracyclines in the treatment of many tumors, but the development …