Abstract Purpose of Review To review state of art and relevant advances in the molecular
genetics and management of ependymomas of children and adults. Recent Findings …

The fifth edition of the World Health Organization Classification of Tumours of the Central
Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and …

Pediatric ependymomas comprise biologically distinct tumor entities with different (epi)
genetics, age distribution and localization, as well as a different prognosis. Regarding risk …

Response criteria for paediatric intracranial ependymoma vary historically and across
different international cooperative groups. The Response Assessment in the Pediatric Neuro …

Background: The clinical management of ependymoma in childhood and adolescence is
complex and the clinicobiopathological correlates of outcome remain poorly understood …

Abstract Background SIOP Ependymoma I was a non-randomised trial assessing event free
and overall survival (EFS/OS) of non-metastatic intracranial ependymoma in children aged 3 …

Brain tumors are the most common solid tumors in children and are associated with high
mortality. The most common childhood brain tumors are grouped as low-grade gliomas …

Ependymal neoplasms are a heterogenous group of neoplasms arising from the progenitors
of the cells lining the ventricular system and the spinal central canal. During the last few …

Simple Summary The current trend in neuropathology directs to the integrated histo-
molecular approach. The traditional concept of histological grade should be complemented …

Background Preclinical studies have suggested that mTOR pathway signaling may be a
potential therapeutic target for childhood ependymoma. Methods A phase II clinical trial …