[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry
F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …
treatment-related effects were carefully reported and used as a basis to calculate safety …
Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment
To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and …
CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and …
[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening
H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …
drug discovery and development has been sky-rocketing, the number of approved drugs has …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
S Dutta, KC Chang, KA Beattie, J Sheng… - Frontiers in …, 2017 - frontiersin.org
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …
drugs from the market and is therefore of major concern to global regulatory agencies and …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Translational models and tools to reduce clinical trials and improve regulatory decision making for QTc and proarrhythmia risk (ICH E14/S7B updates)
DG Strauss, WW Wu, Z Li, J Koerner… - Clinical Pharmacology …, 2021 - Wiley Online Library
After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …