The molecular pathophysiology of psoriatic arthritis—the complex interplay between genetic predisposition, epigenetics factors, and the microbiome

AL Carvalho, CM Hedrich - Frontiers in molecular biosciences, 2021 - frontiersin.org
Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In
a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the …

Cellular and molecular mechanisms in the pathogenesis of classical, vascular, and hypermobile ehlers‒danlos syndromes

N Chiarelli, M Ritelli, N Zoppi, M Colombi - Genes, 2019 - mdpi.com
The Ehlers‒Danlos syndromes (EDS) constitute a heterogenous group of connective tissue
disorders characterized by joint hypermobility, skin abnormalities, and vascular fragility. The …

miR-221-3p drives the shift of M2-macrophages to a pro-inflammatory function by suppressing JAK3/STAT3 activation

L Quero, AN Tiaden, E Hanser, J Roux, A Laski… - Frontiers in …, 2020 - frontiersin.org
Objectives: Macrophages are conventionally classified as pro-inflammatory (M1) and anti-
inflammatory (M2) functional types. There is evidence for a predominance of macrophages …

Delivery of long non-coding RNA NEAT1 by peripheral blood monouclear cells-derived exosomes promotes the occurrence of rheumatoid arthritis via the MicroRNA …

Y Rao, Y Fang, W Tan, D Liu, Y Pang, X Wu… - Frontiers in cell and …, 2020 - frontiersin.org
Emerging evidence has pointed out the importance of long non-coding RNAs (lncRNAs) in
multiple diseases, the knowledge of rheumatoid arthritis (RA)-associated lncRNAs remains …

Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis

S Fromm, CC Cunningham, MR Dunne… - Arthritis research & …, 2019 - Springer
Introduction Angiogenesis is an early event in the pathogenesis of both psoriatic arthritis
(PsA) and rheumatoid arthritis (RA); however, there are striking differences in blood vessel …

Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4

D Liu, Y Fang, Y Rao, W Tan, W Zhou, X Wu… - Journal of molecular …, 2020 - Springer
Fibroblast-derived exosomes have been reported to transfer microRNAs to recipient cells,
where they regulate target gene expression, which is of interest for understanding the basic …

Serum MicroRNA signature as a diagnostic and therapeutic marker in patients with psoriatic arthritis

SM Wade, T McGarry, SC Wade, U Fearon… - The Journal of …, 2020 - jrheum.org
Objective MicroRNA (miRNA) are small endogenous regulatory RNA molecules that have
emerged as potential therapeutic targets and biomarkers in autoimmunity. Here, we …

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis

SM Wade, N Ohnesorge, H McLoughlin, M Biniecka… - …, 2019 - thelancet.com
Background Although neoangiogenesis is a hallmark of chronic inflammatory diseases such
as inflammatory arthritis and many cancers, therapeutic agents targeting the vasculature …

miR-21-5p under-expression in patients with obstructive sleep apnea modulates intermittent hypoxia with re-oxygenation-induced-cell apoptosis and cytotoxicity by …

YC Chen, PY Hsu, MC Su, CH Chin, CW Liou… - International Journal of …, 2020 - mdpi.com
The purpose of this study is to explore the anti-inflammatory role of microRNAs (miR)-21 and
miR-23 targeting the TLR/TNF-α pathway in response to chronic intermittent hypoxia with re …

MicroRNA-23a inhibits osteogenesis of periodontal mesenchymal stem cells by targeting bone morphogenetic protein signaling

Y Zhang, S Li, S Yuan, H Zhang, J Liu - Archives of oral biology, 2019 - Elsevier
Objectives To investigate the role of microRNA-23a (miR-23a) in the osteogenesis of
periodontal mesenchymal stem cells (PDLSCs) in periodontitis. Materials and methods …