Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

An estimated 58 million people have survived tuberculosis since 2000, yet many of them will
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …

Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …

Background It is unknown whether lesions in human TB are hypoxic or whether this
influences disease pathology. Human TB is characterised by extensive lung destruction …

A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …