Within the past 2 years, several angiogenic factors have been fully purified, their amino acid
sequences determined, and their genes cloned. These polypeptides include acidic and …

During wound healing, angiogenic capillary sprouts invade the fibrin/fibronectin-rich wound
clot and within a few days organize into a microvascular network throughout the granulation …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …

Recent in situ hybridization studies had demonstrated a strong increase in vascular
endothelial growth factor (VEGF) mRNA expression in the hyperproliferative epithelium …

Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-β1)
and its receptors (TGF-βRs I and II as well as endoglin) in embryonic vascular assembly and …

When a confluent monolayer of bovine aortic endothelial (BAE) cells is wounded with a
razor blade, endothelial cells (ECs) spontaneously move into the denuded area. If bovine …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Transforming growth factor beta (TGF-beta) is a multifunctional polypeptide that regulates
the proliferation and differentiation of various cells and has an angiogenic effect in vivo …

I. Introduction B ASIC AND acidic fibroblast growth factors (FGFs) are closely related
molecules that show a similar range of biological activities. They differ, however, in some of …

Angiotensin II (ANG II) is known to be a potent growth promoting factor for vascular smooth
muscle cells and fibroblasts but little is known about its influence on growth in endothelial …